This is a continued share/discussion on the new, independent report released last month from the Institute for Safe Medication Practices (ISMP) where they pointed out four adverse drug reactions that stood out from all others in the 2017 FDA data of adverse drug reactions reports received by the FDA.  From severe muscle damage to a deadly viral infection of the brain, their annual report covers it all and we’re talking about it.  (This is part 2 of a 2-part episode)

Show note links:

Some of the specific drugs mentioned in this episode = nivolumab, sacubitril-valsartan, aripiprazole, acetaminophen, ibuprofen, Tramadol, lamotrigine, ciprofloxacin, natalizumab, rituximab, fingolimod, mycophenolate

Drug classes of note = statins, antipsychotics, pain meds, epilepsy meds, oncology meds, antidepressants, opioids

The annual report we’re talking about can be found here –>> ISMP QuarterWatch Annual Report

There were 4 serious adverse drug events highlighted in this annual report, namely…

*Rhabdomyolisis (life-threatening breakdown of skeletal muscles, causing high risk for kidney failure)

*Serotonin or Neuroleptic Malignant Syndrome (life-threatening disruptions of the central nervous system)

*Stevens-Johnson syndrome/Toxic Epidermal Necrolysis, or SJS/TEN (severe skin disorder caused primarily by drugs, reveals as blister-like lesions on areas like the face, eyes, and genitals but can extend beyond these areas)

*Progressive Multifocal Leukoencephalopathy, or PML (a small DNA virus that harmlessly exists in 50% to 70% of the population and is considered latent when harmless…however, once “activated” by certain drugs, for example, can harmfully spread to the brain causing changes in behavior, confused thinking, problems speaking, impaired gait, visual disturbances and even death)

Show credits: Many thanks to the authors of the annual report over at the ISMP.  To learn more about this nonprofit, visit

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Got side effects? Report them to the FDA today.  They are limited in what they can do and how quickly they can act to help protect Americans from harmful adverse drug reactions without your reporting and you can report suspected & confirmed adverse drug reactions. Call 1-800-332-1088 or report online at


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